Sirtuins and Pyridine Nucleotides

Sirtuins and Pyridine Nucleotides Regulation of Ion Channels by Pyridine Nucleotides The Role of NADPH in Antioxidant Scavenging

The silencer information regulator (Sir) family of proteins has attracted much attention during the past decade due to its prominent role in metabolic homeostasis in mammals. The Sir1–4 proteins were first discovered in yeast as nicotinamide adenine dinucleotide (NAD )-dependent deacetylases, which through a gene silencing effect promoted longevity. The subsequent discovery of a homologous sirt...

Pyridine Nucleotide Regulation of Cardiac Intermediary Metabolism Sirtuins and Pyridine Nucleotides Regulation of Ion Channels by Pyridine Nucleotides The Role of NADPH in Antioxidant Scavenging

The pyridine nucleotides NAD and NADP play a pivotal role in regulating intermediary metabolism in the heart. The intracellular NAD /NADH ratio controls flux through various dehydrogenase enzymes involved in both anaerobic and aerobic metabolism and also regulates posttranslational protein modification. The intracellular NADP /NADPH ratio controls flux through the pentose phosphate pathway (PPP...

Regulation of Cell Survival and Death by Pyridine Nucleotides Pyridine Nucleotide Regulation of Cardiac Intermediary Metabolism Sirtuins and Pyridine Nucleotides Regulation of Ion Channels by Pyridine Nucleotides The Role of NADPH in Antioxidant Scavenging

Pyridine nucleotides (PNs), such as NAD(H) and NADP(H), mediate electron transfer in many catabolic and anabolic processes. In general, NAD and NADP receive electrons to become NADH and NADPH by coupling with catabolic processes. These electrons are utilized for biologically essential reactions such as ATP production, anabolism and cellular oxidation-reduction (redox) regulation. Thus, in addit...

Regulation of Cell Survival and Death by Pyridine Nucleotides [Circ Res. 2012;111:611–627] Pyridine Nucleotide Regulation of Cardiac Intermediary Metabolism Sirtuins and Pyridine Nucleotides Regulation of Ion Channels by Pyridine Nucleotides The Role of NADPH in Antioxidant Scavenging

The pyridine nucleotides NAD and NADP play a pivotal role in regulating intermediary metabolism in the heart. The intracellular NAD /NADH ratio controls flux through various dehydrogenase enzymes involved in both anaerobic and aerobic metabolism and also regulates posttranslational protein modification. The intracellular NADP /NADPH ratio controls flux through the pentose phosphate pathway (PPP...

Pyridine nucleotides in erythrocyte metabolism.